The effect of vascular graft and human umbilical cord blood-derived CD34+ stem cell on peripheral nerve healing

AIM: There are many trials concerning peripheral nerve damage causes and treatment options. Unfortunately, nerve damage is still a major problem regarding health, social and economic issues. On this study, we used vascular graft and human cord blood derived stem cells to find an alternative treatment solution to this problem. MATERIAL AND METHODS: We used 21 female Wistar rats on our study. They were anesthetized with ketamine and we studied right hind limbs. On Group 1, we did a full layer cut on the right sciatic nerve. On Group 2, we did a full layer cut on the right sciatic nerve, and we covered synthetic vascular graft on cut area. On Group 3, we did a full layer cut on right sciatic nerve, and we covered the area with stem cell applied vascular graft. RESULTS: At the end of postoperative 8. weeks, we performed EMG on the rats. When we compared healthy and degenerated areas as a result of EMG, we found significant amplitude differences between the groups on healthy areas whereas there was no significant difference on degenerated areas between the groups. Then we re-opened the operated area again to reveal the sciatic nerve cut area, and we performed electron microscope evaluation. On the stem cell group, we observed that both the axon and the myelin sheet prevented degeneration. CONCLUSION: This study is a first on using synthetic vascular graft and cord blood derived CD34+ cells in peripheral nerve degeneration. On the tissues that were examined with electron microscope, we observed that CD34+ cells prevented both axonal and myelin sheath degeneration. Nerve tissue showed similar results to the control group, and the damage was minimal. © 2018 Ali Yilmaz, Abdullah Topcu, Cagdas Erdogan, Levent Sinan Bir, Barbaros Sahin, Gulcin Abban, Erdal Coskun, Ayca Ozkul

Three-particle templates for boosted Higgs

We explore the ability of three-particle templates to distinguish color neutral objects from QCD background. This method is particularly useful to identify the standard model Higgs, as well as other massive neutral particles. Simple cut-based analysis in the overlap distributions of the signal and background is shown to provide a significant rejection power. By combining with other discriminating variables, such as planar flow, and several variables that depend on the partonic template, three-particle templates are used to characterize the influence of gluon emission and color flow in collider events. The performance of the method is discussed for the case of a highly boosted Higgs in association with a leptonically-decaying W boson.Comment: 32 pages, 13 figures. v2: Acknowledgments added, typos fixed. v3: added comparison to filtering method, minor correction and acknowledgment added. The version to appear in Phys. Rev.

An uncommon fetal retention case: Ruptured ventral hernia in a sheep

ΔΕΝ ΔΙΑΤΙΘΕΤΑΙ ΠΕΡΙΛΗΨΗA four-year-old pluriparous sheep was brought to our clinic with the complaints of mild anorexia and a wound on the ventral abdominal area, with part of a dead lamb protruding from this lesion. Clinical examination revealed that there was a fetal retention into the ruptured gravid uterine horn that was trapped within a ventral hernia. At herniorrhaphy after removing the dead fetus, strong connections between the uterine and abdominal wall and chronic scars/necrosed tissues were detected in the wound edges, which revealed the long time lapse between the unnoticed herniation-tearing and surgery. Although many ventral hernia cases have been reported in ovine pregnancies, the high maternal resilience in this ruptured hysterocele case, which had a two-week-old history at minimum, is clinically remarkable

Near-linear dynamics in KdV with periodic boundary conditions

Near linear evolution in Korteweg de Vries (KdV) equation with periodic boundary conditions is established under the assumption of high frequency initial data. This result is obtained by the method of normal form reduction

A rare case of juvenile-onset Behçet's disease: Fournier’s gangrene followed by intestinal involvement

Behçet's disease (BD) is a multisystemic, inflammatory disease with still unknown etiology and rarely seen in childhood. BD has worse prognosis in young, male patients. BD exacerbations may be triggered by viral, bacterial, and other undefined antigenic stimuli in genetically predisposed individuals. Fournier’s gangrene (FG) is a rapidly progressive, necrotizing fasciitis of the genital and perineal regions with high morbidity and mortality. FG is usually seen in immunocompromised patients and may be triggered by local factors such as trauma, trombosis, and vasculitis. Here, we present a adolescent, male patient with juvenile-onset BD who developed FG and afterwards entero-Behçet. This unique assocation without any other underlying immunocompromised condition is discussed.Keywords: Behçet's disease, colitis, Fournier’s gangrene, juvenile onse

Effect Of G2706A and G1051A polymorphisms of the ABCA1 gene on the lipid, oxidative stress and homocystein levels in Turkish patients with polycystıc ovary syndrome

<p>Abstract</p> <p>Background</p> <p>Obesity, insulin resistance and hyperandrogenism, crucial parameters of Polycystic ovary syndrome (PCOS) play significant pathophysiological roles in lipidemic aberrations associated within the syndrome. Parts of the metabolic syndrome (low HDL and insulin resistance) appeared to facilitate the association between PCOS and coronary artery disease, independently of obesity. ABCA1 gene polymorphism may be altered this components in PCOS patients.</p> <p>In this study, we studied 98 PCOS patients and 93 healthy controls. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, insulin, malondialdehyde, nitric oxide, disulfide levels and ABCA genetic study.</p> <p>Results</p> <p>In PCOS group fasting glucose, DHEAS, 17-OHP, free testosterone, total-cholesterol, triglyceride, LDL-cholesterol and fibrinogen were significantly different compare to controls. The genotype ABCA G2706A distribution differed between the control group (GG 60.7%, GA 32.1%, AA 7.1%) and the PCOS patients (GG 8.7%, GA 8.7%, AA 76.8%). The frequency of the A allele (ABCAG2706A) was higher in PCOS patients than control group with 13,0% and 23,2%, respectively. In this study, the homocystein and insulin levels were significantly higher in PCOS patients with ABCA G1051A mutant genotype than those with heterozygote and wild genotypes.</p> <p>Conclusions</p> <p>We found higher percentage of AA genotype and A allele of ABCA G2706A in PCOS patients compare to controls. The fasting insulin and homocystein levels were significantly higher in PCOS patients with ABCA G1051A mutant genotype than those with heterozygote and wild genotypes.</p

Product factorability of integral bilinear operators on Banach function spaces

[EN] This paper deals with bilinear operators acting in pairs of Banach function spaces that factor through the pointwise product. We find similar situations in different contexts of the functional analysis, including abstract vector lattices¿orthosymmetric maps, C¿-algebras¿zero product preserving operators, and classical and harmonic analysis¿integral bilinear operators. Bringing together the ideas of these areas, we show new factorization theorems and characterizations by means of norm inequalities. The objective of the paper is to apply these tools to provide new descriptions of some classes of bilinear integral operators, and to obtain integral representations for abstract classes of bilinear maps satisfying certain domination properties.The first author was supported by TUBITAK-The Scientific and Technological Research Council of Turkey, Grant No. 2211/E. 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